iACT Stealth Cells™
Induced Allogenic Cell Tolerance (iACT) Stealth Cells™.
iACT Stealth Cells™ Immune Evasion Mechanism
Our groundbreaking technology enables allograft transplantation by cloaking the cells from the patients immune system. iACT Stealth Cells™ technology with immune-modulatory genes allows the acceptance of allografts without the need for systemic immune suppression. Equipping pluripotent stem cells (iPSCs) with this technology will allow the same stem cell line to be used for differentiation and ultimately transplantation into any individual.
This technology is carefully gene edited into stem cells to provide antigenic escape. This mechanism allows the transplanted cell therapy to remain undetected by the patient's immune system removing the need for immune suppression therapy.
Cells equipped with iACT Stealth Cells™ technology avoid allograft immune recognition.
iACT Stealth Cells™ remove the need for patients to undergo immuno-suppressive treatments.
iACT Stealth Cells™ pave the way for universal “off-the-shelf” regenerative medicine cell therapies.
iACT Stealth Cells™ are Engineered Based on Pluristyx's Years of Expertise
iACT Stealth Cell™ is a Holistic Approach
All components of the immune response to an allograft are carefully addressed while placing special attention to the intricate interplay between each factor. Since disabling the immune system’s ability to recognize and eliminate “non-self” cells is inherently dangerous, it is imperative to combine such approaches with reliable safety mechanisms such as our FailSafe®cell system.