iACT Stealth Cells

Induced Allogenic Cell Tolerance (iACT) Stealth Cells™.

iACT Stealth Cells Immune Evasion Mechanism

Our groundbreaking technology enables allograft transplantation by cloaking the cells from the patients immune system. iACT Stealth Cells™ technology with immune-modulatory genes allows the acceptance of allografts without the need for systemic immune suppression. Equipping pluripotent stem cells (iPSCs) with this technology will allow the same stem cell line to be used for differentiation and ultimately transplantation into any individual.

This technology is carefully gene edited into stem cells to provide antigenic escape. This mechanism allows the transplanted cell therapy to remain undetected by the patient's immune system removing the need for immune suppression therapy.

Cells equipped with iACT Stealth Cells™ technology avoid allograft immune recognition.

iACT Stealth Cells™ remove the need for patients to undergo immuno-suppressive treatments.

iACT Stealth Cells™ pave the way for universal “off-the-shelf” regenerative medicine cell therapies.

iACT Stealth Cells are Engineered Based on Pluristyx's Years of Expertise

iACT Stealth Cells™ are created using licensed technology, internal IP, and know-how to allow allogenic cells to evade immune system rejection without the need for immune suppression. This proprietary approach was generated from Pluristyx's years of experience in the stem cell field.
 
Our specialized approach to generating immune privileged cells is a significant achievement. Immune recognition can trigger a rapid inflammatory response that lead to the activation of the host's immune cell based responses; including macrophages, Natural Killer (NK) and T-cells.
 
These responses can occur rapidly – within minutes in case of hyperacute responses – or over years in chronic responses rejection.

iACT Stealth Cell is a Holistic Approach

All components of the immune response to an allograft are carefully addressed while placing special attention to the intricate interplay between each factor. Since disabling the immune system’s ability to recognize and eliminate “non-self” cells is inherently dangerous, it is imperative to combine such approaches with reliable safety mechanisms such as our FailSafe®cell system.

Patient recovering from cell therapy treatment incorporating iACT Stealth Cells

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FailSafe®

Technology
A reliable safeguard against transplants becoming tumorigenic – any unwanted cells can be eliminated with a simple source of drug treatment.
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REA Process & Licensing

Try Before You Buy
By offering the Research Evaluation Agreement you can gain access to our modified and non-modified cellular products for evaluation with our Try Before You Buy model. A smaller upfront payment limits your risk. Once you see the successful results, you can then enter into a license agreement with us panCELLa / Pluristyx.
Learn More

Catalog & Gene Editing

Solution
Clients can effortlessly access and assess premium cell banks of gene-edited iPSCs, integrating our exclusive proprietary modifications, available in both research and clinical grades, all from a single, reliable source.
Learn More

FailSafe®

Technology
A reliable safeguard against transplants becoming tumorigenic – any unwanted cells can be eliminated with a simple source of drug treatment.
Learn More

REA Process & Licensing

Try Before You Buy
By offering the Research Evaluation Agreement you can gain access to our modified and non-modified cellular products for evaluation with our Try Before You Buy model. A smaller upfront payment limits your risk. Once you see the successful results, you can then enter into a license agreement with us panCELLa / Pluristyx.
Learn More

Catalog & Gene Editing

Solution
Clients can effortlessly access and assess premium cell banks of gene-edited iPSCs, integrating our exclusive proprietary modifications, available in both research and clinical grades, all from a single, reliable source.
Learn More

Contact us to learn more about iACT


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