A reliable safeguard against transplants becoming tumorigenic – any unwanted cells can be eliminated with a simple course of drug treatment.
Induced pluripotent stem (iPSCs) are a paradigm-shifting effect on regenerative medicine, and powerful new treatment against diseases underlined by cell loss, tissue degeneration and aging.
The panCELLa technology means to quantify the safety level of a prospective cell therapy.
panCELLa’s exclusive FailSafe® uses a suicide gene (HSV-TK) and an FDA-approved prodrug (Gancivlovir).
A therapeutic batch of cells are considered FailSafe® if all of the cells have a functional safety switch.
We have developed
The FailSafe® cell system
Pluripotent stem cells engineered with FailSafe® are capable of differentiation into a multitude of potential therapeutic cell types, showing that FailSafe® does not interfere with their properties.
With a suicide gene place into a locus essential for cell life, all the transplanted cells are eliminated regardless of their proliferative status. FailSafe® is unique in that, rather than kill all cells, it merely eliminates only actively dividing cells, ensuring that differentiated therapeutic cells are not accidently killed off and can continue to provide benefit to patients