A safety switch designed for cell therapy.
Our FailSafe® Mechanism for Cell Therapy
We Have a Solution: The FailSafe® Cell System
FailSafe® Engineered Stem Cells
Pluripotent stem cells engineered with FailSafe® are capable of differentiation into a multitude of potential therapeutic cell types such as pancreatic islets, mesenchymal stem cells and hematopoietic stem cells, showing that FailSafe® does not interfere with their functionality.
With a suicide gene placed into a locus essential for cell life, all the transplanted cells are eliminated regardless of their proliferative status. FailSafe® is unique in that, rather than kill all cells, it merely eliminates only actively dividing cells, ensuring that differentiated therapeutic cells are not accidentally killed off and can continue to provide benefit to patients.