Cellular Reprogramming
Proprietary Footprint-Free RNA Reprogramming Method to Generate iPSCs
Cellular Reprogramming with Pluristyx's Proprietary Footprint-Free mRNA
Pluristyx has pioneered an approach to cellular reprogramming that utilizes a non-integrating, footprint-free method to generate induced Pluripotent Stem Cells (iPSCs). This innovative technique leverages the power of messenger RNA (mRNA) engineered to introduce and express transcription factors that transform adult cells into iPSCs.
Donors appropriate
for clinical use
Pluristyx has worked hard to source regulatory-compliant donors that are appropriate for clinical use.
Non-integrating, footprint-free mRNA technology
Pluristyx uses non-modified mRNA constructs that efficiently reprogram adult cells into genetically stable iPSCs.
Rigorously tested
to ensure success
Pluristyx uses non-modified mRNA constructs that efficiently reprogram adult cells into genetically stable iPSCs.
Freedom
to Operate
Our proprietary mRNA reprogramming technology provides groups with full Freedom to Operate for their chosen clinical indication and most major geographic territories.
Donors appropriate
for clinical use
Pluristyx has worked hard to source regulatory-compliant donors that are appropriate for clinical use.
Non-integrating, footprint-free mRNA technology
Pluristyx uses non-modified mRNA constructs that efficiently reprogram adult cells into genetically stable iPSCs.
Rigorously tested
to ensure success
Pluristyx uses non-modified mRNA constructs that efficiently reprogram adult cells into genetically stable iPSCs.
Freedom
to Operate
Our proprietary mRNA reprogramming technology provides groups with full Freedom to Operate for their chosen clinical indication and most major geographic territories.
mRNA Sequences
The heart of our technology lies in mRNA sequences that utilize non-modified nucleotides that organize into stable structures to provide long-lasting expression of transcription factors that guide somatic cells on their remarkable journey towards pluripotency. Unlike traditional methods that rely on the integration of genetic material, Pluristyx’s approach ensures a footprint-free process to produce early passage, genetically stable iPSCs that can be used as an ideal starting material for downstream genetic engineering and GMP manufacturing.
Rigorously Tested
Pluristyx iPSCs are rigorously tested and consistently demonstrate their capacity to transform into various cell lineages, including neurons, cardiomyocytes, hepatocytes, and more. Our unmodified iPSCs then then selected based on their trilineage differentiation potential for the insertion of our FailSafe® and iACT Stealth Cells™ technologies, which provide the unparalleled safety and immune evasion abilities, respectively, that allows these cells to be used as the starting material for a multitude of therapeutic applications.
Our commitment to innovation and excellence in cellular reprogramming ensures that Pluristyx’s iPSCs stand at the forefront of regenerative medicine. Whether for drug discovery, disease modeling, or cell-based therapies, our proprietary footprint-free RNA reprogramming method empowers researchers and clinicians with a powerful tool to unlock the full potential of induced pluripotent stem cells. Join us in revolutionizing the future of medicine, one reprogrammed cell at a time.
Rigorously Tested
Pluristyx iPSCs are rigorously tested and consistently demonstrate their capacity to transform into various cell lineages, including neurons, cardiomyocytes, hepatocytes, and more. Our unmodified iPSCs then then selected based on their trilineage differentiation potential for the insertion of our FailSafe® and iACT Stealth Cells™ technologies, which provide the unparalleled safety and immune evasion abilities, respectively, that allows these cells to be used as the starting material for a multitude of therapeutic applications.
Our commitment to innovation and excellence in cellular reprogramming ensures that Pluristyx’s iPSCs stand at the forefront of regenerative medicine. Whether for drug discovery, disease modeling, or cell-based therapies, our proprietary footprint-free RNA reprogramming method empowers researchers and clinicians with a powerful tool to unlock the full potential of induced pluripotent stem cells. Join us in revolutionizing the future of medicine, one reprogrammed cell at a time.